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In our model, major lesions could be detected in the liver and spleen at 3 and 4 dpi and in the brain at 5 dpi or later in mice infected with RVFV (Fig. 2). We confirmed that rZH501 with either the Y259H (Gn) or R1182G (Gc) mutation failed…

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Any=No of patients reporting any adverse event; serious=No of patients reporting any serious adverse event (as defined by each study); withdrawals=No of patients withdrawn from study because of adverse events; liver=No of patients with…

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Even though our results suggest that DC activation plays an important role in the rescue of exhausted CD8 T cells, it is important to take into account that the presence of conventional CD4 T cells was required for the rescue of exhausted…

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